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Biomimetic Peptides

Tetrapeptide-30; skin-like peptides; biomimetic peptides Aging is a natural process, but it can be accelerated by internal and external influences. Such factors exacerbate structural and functional changes in skin and hair, altering their appearance faster than natural aging processes. Biomimetic peptides, also called biomimetic peptides, can be used to mimic the activity of naturally occurring peptides and have been shown to have a variety of biological effects, including anti-inflammatory and antimicrobial activities.


Biomimetic peptides in cosmetics

Biomimetic peptides are artificial peptides designed to mimic the structure and function of natural peptides found in the human body. They are widely used in the cosmetics industry to improve and treat skin. These biomimetic peptides are based on the skin’s own structures and allow corresponding nature-related product claims. The quality-controlled, synthetic peptides mimic the activity of skin’s own peptides and trigger regeneration processes in the skin. Due to their skin-like properties, they influence aging in a physiological way without being aggressive or irritating. Biomimetic peptides that strengthen and rebalance the skin and hair when confronted with daily stressors and harmonize the aging process are increasingly in demand.

Biomimetic peptides can be used in formulations to reduce wrinkles and lines, increase skin hydration, improve skin tone and support the natural process of skin renewal. They offer the kind of product performance consumers want: ageless beauty for skin and hair with skin-smart technologies.

Cosmacon offers the cosmetic service of a development with biomimetic peptides, so that you too can soon offer such a product under your brand.


Skin-like peptides for the vital appearance of skin and hair

In the skin, physiological depletion due to internal and external influences is manifested by the reduction of fibroblasts, decreased formation of extracellular matrix components such as collagen, elastin, glycosaminoglycans. This accelerates signs of aging, such as wrinkles, sagging skin, changes in skin tone, rough texture.

In hair, depleting stressors lead to decrease in melanin formation, premature graying, decreased hair formation, split ends, rough texture, increased hair loss.

Biomimetic peptides, also called biomimetic peptides can maintain and revitalize the vital appearance of skin and hair longer. With their molecules mimicking the skin’s own amino acid sequences, biomimetic peptides set the body’s own repair mechanisms in motion and partially override aging. They strengthen the skin structure, reduce wrinkles and can be combined well with other skin care substances, e.g. vitamins.

Due to their affinity to the skin, they are considered recommendable. They can be processed well in O/W and W/O emulsions and are suitable for all skin types.

Biomimetic peptides are of particular importance in anti-aging and repair care for both skin and hair.

In hair care they are used in hair treatments, masks, boosters, serums, shampoos with repair effect.


Some examples of biomimetic peptides in cosmetics

Copper Tripeptide-1: Healthy skin

INCI: Copper Tripeptide-1

Carrier peptide with naturally occurring amino acids and copper promotes skin health, corrects signs of aging, supports collagen and elastin formation, increases fibroblast activity, reduces inflammatory reactions, prevents signs of aging.

As studies have shown, the concentration of natural copper tripeptide in plasma decreases over the years. If it is 200 ng/ml in the plasma of 20-year-olds, it is 80 ng/ml in 60-year-olds.

The many biological effects, such as stimulation of immune cells, antioxidant, anti-inflammatory effects, have also been proven. In addition, biomimetic peptide promotes repair functions in the skin and improves skin firmness.

It also enlarges hair follicles, and stimulates hair growth.

Manufacturer: e.g. Evonik


Tetrapeptide-21: Strong skin matrix

INCI: Tetrapeptide-21

This biomimetic peptide has proven to be a booster for the extracellular matrix.

It boosts the activity of collagen, hyaluronic acid and fibronectin. The skin regains elasticity and its surface becomes smoother.

The molecule uses the skin’s amino acid sequence to stimulate the reduction of lines and wrinkles with this information. It also increases skin firmness, relieves skin redness and roughness.

Manufacturer: e.g. Evonik


Tetrapeptide-4: Anti-gravity

INCI: Tetrapeptide-4

This biomimetic peptide has convincing anti-gravity effects and is therefore ideal for counteracting sagging skin, firming facial contours and smoothing wrinkles. It promotes the formation of collagen and other components of the extracellular matrix. Consequently, it is suitable for use in anti-aging products.

Manufacturer: e.g. Evonik


Tetrapeptide-61: New Balance

INCI: Tetrapeptide-61

The biomimetic peptide strengthens the extracellular matrix, rebalances skin processes and renews the skin’s appearance. It promotes skin vitality and specifically targets aging fibroblasts and keratinocytes, restoring their energy and alleviating stressors that lead to premature aging.

Manufacturer: e.g. Evonik


Tetrapeptide-30: Uniformly fair skin

INCI: Tetrapeptide-30

This biomimetic peptide reduces pigmentation spots, brightens the skin, reduces acne scars and melasma in all skin tones. It also shows significant anti-inflammatory effects and relieves the symptoms of sensitive skin, redness and irritation.

It is mainly used in products for skin whitening, anti-aging products for more even skin tone and pigmentation-regulating hand and décolleté care.

Manufacturer: e.g. Evonik


Copper tripeptide-34: Vitality for hair

INCI: Copper Tripeptide-34

Carrier peptide with natural amino acids and copper promotes healthy hair growth cycle, strengthens and enlarges hair follicles, improves scalp condition and hair quality. The biomimetic peptide rebalances the hair life cycle and restores strength to aging hair.

Manufacturer: e.g. Evonik


Biomimetic peptides give regenerating signals

Biomimetic peptides give skin and hair the signal to regenerate and are well tolerated. They allow nature-based product claims because they are modeled on the skin’s own amino acid sequences. Biomimetic peptides have great potential especially in regenerating and repairing, but also in protective skin and hair care, which Cosmacon is happy to realize for your products.


Read also our blog articles on the topics:


Bioactive peptides




 Cosmeceutical product consisting of biomimetic peptides: antiaging effects in vivo and in vitro.; Gazitaeva, Z. I., Drobintseva, A. O., Chung, Y., Polyakova, V. O., & Kvetnoy, I. M. Clinical, cosmetic and investigational dermatology 2017, 11-16.

Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of alopecia areata.; Rinaldi, F., Marzani, B., Pinto, D., & Sorbellini, E.  Journal of Dermatological Treatment 201930(6), 588-593.

QR678 & QR678 Neo Hair Growth Formulations: A Cellular Toxicity & Animal Efficacy Study.; Kapoor R, Shome D, Vadera S, Kumar V, Ram MS.Plast Reconstr Surg Glob Open. 2020 Aug 25;8(8):e2843.

Bioactive Peptides: Applications and Relevance for Cosmeceuticals.; Lima TN, Pedriali Moraes CA. Cosmetics. 2018; 5(1):21.

Directed Discovery of Tetrapeptide Emulsifiers.; Scott GG, Börner T, Leser ME, Wooster TJ, Tuttle T.Front Chem. 2022 Feb 17;10:822868.