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T-EGF: breakthrough with transdermal epidermal growth factor

T-EGF; transdermal epidermal growth factor

The skin is our largest organ and, at the same time, an almost impenetrable barrier. Until now, many active ingredients, especially large molecules such as proteins, have been unable to penetrate the skin. But this is where a groundbreaking innovation comes in: transdermal epidermal growth factor (T-EGF).

What is T-EGF?

T-EGF is a fusion of the classic epidermal growth factor (EGF) and a special peptide called TD1. This peptide was developed to overcome the skin’s barrier function and allow large molecules such as EGF to enter the epidermis. This makes T-EGF a milestone in active ingredient technology, as it combines the biological activity of EGF with a novel transdermal efficiency.

Mode of action of transdermal epidermal growth factor

While conventional EGF can only penetrate the skin to a limited extent, T-EGF manages to penetrate the deeper layers of the skin in a targeted and effective manner. There it unfolds a multitude of positive effects:

– Cell proliferation and regeneration: T-EGF stimulates the formation of new skin cells and promotes wound healing.

– Slowing down skin ageing: By supporting cell signalling, the ageing of epidermal cells is delayed.

– Barrier repair: Clinical studies show a significant reduction in transepidermal water loss (TEWL) – up to 29% after 28 days.

– Moisture increase: Studies showed an increase in water content in the stratum corneum of over 30%.

– Reduction of redness: After four weeks of use, a significant decrease in the a* value was measurable, which corresponds to a visible reduction in skin redness.

The transdermal epidermal growth factor thus combines several key functions for healthy, youthful skin.

Advantages for cosmetics

The strength of T-EGF lies not only in its effectiveness, but also in its production:

– Sustainable, microbial biosynthesis without animal components.

– Highly pure, bioavailable form of the active ingredient.

– Clinically effective even in very low doses (0.0002%).

This makes transdermal epidermal growth factor ideal for the development of modern cosmetic products that are designed to deliver fast and visible results.

A particularly exciting variant of the transdermal epidermal growth factor comes from GFN-Selco. Here, T-EGF is provided in the form of a synergistic peptide combination: sr-(hexapeptide-40-oligopeptide-232-sh-oligopeptide-1).

  • Hexapeptide-40 has a modulating effect on the skin barrier and supports penetration.
  • Oligopeptide-232 stimulates skin cell renewal and contributes to visible skin rejuvenation.
  • sh-Oligopeptide-1 (recombinant EGF) acts as a key protein for cell proliferation, regeneration and anti-ageing.

This combination enhances the biological activity of T-EGF and provides a particularly effective transdermal formulation of the epidermal growth factor with clinically proven effects.

This makes the GFN Selco active ingredient an attractive option for high-performance cosmetic products that simultaneously target skin repair, anti-ageing and the reduction of redness.

Product ideas with transdermal epidermal growth factor

– Repair serums: for targeted restoration of the skin barrier and reduction of redness.

  • Anti-ageing creams with T-EGF as the key active ingredient for visible skin rejuvenation.
  • After-treatment care to support regeneration following dermatological treatments.
  • Hydration boosters: to increase moisture content in the stratum corneum.

All these products benefit from the fact that the transdermal epidermal growth factor actually reaches the skin and works where it is needed.

Conclusion:

T-EGF is much more than a further development of classic EGF: it is a real breakthrough in active ingredient research for skin care. With its ability to penetrate deep into the skin, regenerate cells, moisturise and reduce redness, T-EGF sets new standards for modern, scientifically based cosmetic products.

Cosmacon supports brands in incorporating transdermal epidermal growth factor into innovative formulations. With our expertise and network, we develop tailor-made formulations based on the latest science. Feel free to contact us today to start your project.

For a quick market entry, our partner Tojo Cosmetics offers ready-made private label products with innovative active ingredients such as T-EGF – available immediately.

Literature:

New clinical findings on T-EGF: effective deep repair of the skin and reduction of redness; L. Zhang, Y. Liu; sofw journal 1+2-2025