Acetyl Tetrapeptide-5: A versatile active ingredient for eye care

4. May 2026
Acetyl Tetrapeptide-5 formula structure of the molecule

What is Acetyl Tetrapeptide-5?

Acetyl Tetrapeptide-5 is a synthetic peptide known in the cosmetics industry for its skin-care and, in particular, decongestant properties. The active ingredient is often used in eye care products to reduce puffiness, dark circles, and fine lines.

 

 

Physicochemical characteristics:

INCI name: Acetyl Tetrapeptide-5

CAS number: 820959-17-9

Molecular structure: Tetrapeptide with acetyl modification

Solubility: Water-soluble

Appearance: White to cream-colored powder

Recommended concentration: 0.001-0.25%

Purity: ≥98%

 

 

How does Acetyl Tetrapeptide-5 work?

The main mechanism of Acetyl Tetrapeptide-5 is based on its ability to reduce the permeability of blood vessels. This minimizes fluid accumulation in the tissue, which in turn reduces dark circles and puffiness around the eyes. Acetyl tetrapeptide-5 also acts as an inhibitor of angiotensin-converting enzyme (ACE), thereby helping to improve microcirculation.

Effectiveness and recommended concentration:

Studies show that a concentration of 0.001-0.25% acetyl tetrapeptide-5 can cause significant improvements in eye puffiness and dark circles. In an in vivo test, a visible reduction in dark circles and puffiness was observed after just 14 and 28 days.

 

 

Benefits of acetyl tetrapeptide-5

Acetyl tetrapeptide-5 offers a variety of benefits for skin care:

  • Reduction of dark circles and puffiness:By inhibiting vascular permeability and improving microcirculation, the appearance of dark circles and puffiness is reduced.
  • Moisturizing:The active ingredient improves skin moisture by reducing transepidermal water loss (TEWL).
  • Skin tightening:Acetyl Tetrapeptide-5 helps improve skin elasticity and smooth fine lines.
  • Anti-inflammatory:It can help reduce skin irritation and promote skin soothing.

 

 

Disadvantages of Acetyl Tetrapeptide-5

Despite its positive properties, there are some limitations:

  • Effectiveness depends on concentration:Low concentrations below 0.5% often show only minor effects.
  • Long-term results require continuous use:The effect is not permanent and requires regular use.
  • Cost factor:High-quality peptides are often expensive to manufacture, which can affect the final price of cosmetic products.

 

 

Areas of application in cosmetics

Thanks to its versatile properties, acetyl tetrapeptide-5 is particularly suitable for the following cosmetic products:

  • Eye serums and creams:Ideal for reducing bags under the eyes and dark circles.
  • Anti-aging creams:To improve skin elasticity and moisture supply.
  • BB and CC creams:For a brightening and decongesting effect.
  • Moisturizing masks:For deep hydration and soothing of the skin.

 

 

Conclusion

Acetyl tetrapeptide-5 is a powerful active ingredient with proven effectiveness in reducing dark circles, puffiness, and fine lines. Due to its excellent skin compatibility, it is ideal for sensitive skin areas and can be used in numerous cosmetic products.

If you would like to develop an innovative cosmetic product with acetyl tetrapeptide-5 for your brand, Cosmacon GmbH is your competent partner. Our experts can develop highly effective, customized formulations that are in line with the latest scientific findings and successfully position your brand. Contact us to turn your ideas into reality!

 

 

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