{"id":19671,"date":"2026-03-15T15:03:39","date_gmt":"2026-03-15T14:03:39","guid":{"rendered":"https:\/\/www.cosmacon.de\/?post_type=encyclopedia&#038;p=19671"},"modified":"2026-03-15T19:06:37","modified_gmt":"2026-03-15T18:06:37","slug":"zinc-pca-in-cosmetics-effects-formulation-and-regulatory","status":"publish","type":"encyclopedia","link":"https:\/\/www.cosmacon.de\/en\/glossary\/zinc-pca-in-cosmetics-effects-formulation-and-regulatory\/","title":{"rendered":"Zinc PCA in Cosmetics \u2013 Effects, Formulation and Regulatory"},"content":{"rendered":"<p>&nbsp;<\/p>\n<h3>Quick Answer \/ Definition<\/h3>\n<p>Zinc PCA (INCI: <i>Zinc PCA<\/i>) is the zinc salt of pyrrolidone carboxylic acid (PCA), a natural component of the skin\u2019s Natural Moisturizing Factor (NMF). The active ingredient combines the sebum-regulating properties of zinc with the moisture-binding properties of PCA. In cosmetic formulations, zinc PCA is primarily used in products for oily, blemished, or acne-prone skin. Typical concentrations range from 0.1\u20131.0%.<\/p>\n<h3>What is zinc PCA from a chemical perspective?<\/h3>\n<p>Zinc PCA is a salt composed of zinc ions (Zn\u00b2\u207a) and L-pyrrolidone carboxylate (PCA).<\/p>\n<p>PCA is a natural component of the skin\u2019s Natural Moisturizing Factor (NMF) and acts as a hygroscopic moisture-retaining factor. When combined with zinc, it forms an active ingredient that simultaneously addresses hydration and sebum regulation.<\/p>\n<h3>Brief characterization:<\/h3>\n\n<table id=\"tablepress-465\" class=\"tablepress tablepress-id-465\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\"><strong>Parameter<\/strong><\/th><th class=\"column-2\"><strong>Description<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">INCI<\/td><td class=\"column-2\">Zinc PCA<\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">CAS<\/td><td class=\"column-2\">15454-75-8<\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">Chemical class <\/td><td class=\"column-2\">Metal amino acid derivative<\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">Solubility <\/td><td class=\"column-2\">Water-soluble<\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">Typical dosage <\/td><td class=\"column-2\">0,1\u20131,0 %<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-465 from cache -->\n<h3>What effect does zinc PCA have on the skin?<\/h3>\n<p>Zinc PCA has sebum-regulating, antimicrobial, and mild anti-inflammatory properties.<\/p>\n<p>Typical effects in cosmetic formulations: Sebumeter measurements have shown that applying a 1% zinc PCA solution over several weeks can result in a measurable reduction in sebum production.<\/p>\n<ul>\n<li>Reduction of excessive sebum production<\/li>\n<li>Support of the skin barrier<\/li>\n<li>Improvement in skin feel for oily skin<\/li>\n<li>Antimicrobial effect against skin-relevant microorganisms<\/li>\n<\/ul>\n<h3>Why is zinc PCA particularly beneficial for blemish-prone skin?<\/h3>\n<p>Zinc plays an important role in skin metabolism and in the enzymatic processes of the skin barrier.<\/p>\n<p>Cosmetic relevance: This is why zinc PCA is frequently used in acne serums, facial toners, and clarifying skincare products.<\/p>\n<ul>\n<li>Inhibition of sebum-associated skin processes<\/li>\n<li>Support of skin microbiome balance<\/li>\n<li>Improvement of the appearance of oily skin<\/li>\n<\/ul>\n<h3>What antimicrobial properties does zinc PCA possess?<\/h3>\n<p>Zinc ions can inhibit the growth of certain microorganisms.<\/p>\n<p>Typical microbiological effects: These properties make zinc PCA particularly interesting for:<\/p>\n<ul>\n<li>Inhibition of <i>Staphylococcus aureus<\/i><\/li>\n<li>Inhibition of <i>Cutibacterium acnes<\/i><\/li>\n<li>Inhibition of <i>Malassezia furfur<\/i><\/li>\n<\/ul>\n<ul>\n<li>Acne care<\/li>\n<li>Scalp care<\/li>\n<li>Deodorant formulations<\/li>\n<\/ul>\n<h3>In which cosmetic products is zinc PCA used?<\/h3>\n<p>The active ingredient is versatile.<\/p>\n<p>Typical applications: Zinc PCA can be used in both leave-on and rinse-off products.<\/p>\n<ul>\n<li>Facial toners for oily skin<\/li>\n<li>Anti-acne serums<\/li>\n<li>Mattifying day creams<\/li>\n<li>Scalp tonics<\/li>\n<li>Shampoos for oily scalps<\/li>\n<li>After-sun products<\/li>\n<li>Makeup formulations<\/li>\n<\/ul>\n<h3>What challenges are there when formulating with zinc PCA?<\/h3>\n<p>Zinc ions tend to form insoluble complexes with certain anions. This can lead to cloudiness or precipitation.<\/p>\n<p><strong>Typical formulation issues:<\/strong><\/p>\n<p>These aspects are crucial in the practical development of cosmetic formulations.<\/p>\n<ul>\n<li>Complex formation with phosphates<\/li>\n<li>Reaction with carbonates<\/li>\n<li>Interactions with chelating agents<\/li>\n<li>Precipitation with certain polymer structures<\/li>\n<\/ul>\n<ol>\n<li>Adjust pH range to 4.5\u20136.5<\/li>\n<li>Avoid phosphate buffers<\/li>\n<li>Check electrolyte stability<\/li>\n<li>Test metal ion compatibility<\/li>\n<li>Conduct stability testing over 12\u201324 months<\/li>\n<\/ol>\n<h3>What synergistic combinations with metal-PCA are possible?<\/h3>\n<p>Multiple metal ions can be used together to support physiological skin processes.<\/p>\n<p><strong>An example of such a combination is a mixture of:<\/strong><\/p>\n<p>PHYSIOGENYL\u00ae PowderThis combination combines:Such systems are frequently used in skin-physiologically oriented care products.<\/p>\n<ul>\n<li>Maltodextrin<\/li>\n<li>Sodium PCA<\/li>\n<li>Magnesium PCA<\/li>\n<li>Zinc PCA<\/li>\n<li>Manganese PCA<\/li>\n<\/ul>\n<ul>\n<li>Humectants<\/li>\n<li>Trace elements<\/li>\n<li>Enzymatic cofactors<\/li>\n<\/ul>\n<h3>What is the regulatory status of Zinc PCA?<\/h3>\n<p>Zinc PCA is permitted for cosmetic use in the European Union.<\/p>\n<p>Regulatory Key Points:<\/p>\n<ul>\n<li>INCI: Zinc PCA<\/li>\n<li>CAS Number: 15454-75-8<\/li>\n<li>No restrictions under Regulation (EC) No. 1223\/2009<\/li>\n<li>Safety assessment is conducted for the finished product<\/li>\n<\/ul>\n<p>As part of the CPSR, the following must be assessed, among other things:<\/p>\n<ul>\n<li>Exposure<\/li>\n<li>Purity of the raw material<\/li>\n<li>Heavy metal content<\/li>\n<li>Stability of the final formulation<\/li>\n<\/ul>\n<h3>We are pleased to work with these active ingredients containing zinc PCA:<\/h3>\n\n<table id=\"tablepress-467\" class=\"tablepress tablepress-id-467\">\n<thead>\n<tr class=\"row-1\">\n\t<th class=\"column-1\"><strong>Tradename<\/strong><\/th><th class=\"column-2\"><strong>Supplier<\/strong><\/th><th class=\"column-3\"><strong>INCI Name<\/strong><\/th><th class=\"column-4\"><strong>Remarks<\/strong><\/th>\n<\/tr>\n<\/thead>\n<tbody class=\"row-striping row-hover\">\n<tr class=\"row-2\">\n\t<td class=\"column-1\">Reaqua Zinc PCA<\/td><td class=\"column-2\">Guangzhou Reachin Chemical Co., Ltd.<\/td><td class=\"column-3\">Zinc PCA , Aqua<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-3\">\n\t<td class=\"column-1\">Zinc PCA<\/td><td class=\"column-2\">Alpha Environmental<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-4\">\n\t<td class=\"column-1\">Zinc PCA<\/td><td class=\"column-2\">COSROMA<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-5\">\n\t<td class=\"column-1\">Zinc PCA<\/td><td class=\"column-2\">Suzhou Greenway Biotech Co.,Ltd<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-6\">\n\t<td class=\"column-1\">iMoist Zinc PCA<\/td><td class=\"column-2\">KimiKa, LLC (Formerly Cosphatech)<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-7\">\n\t<td class=\"column-1\">Zinc Pyrrolidone Carboxylic Acid<\/td><td class=\"column-2\">Shanghai Oli Enterprises Co.,Ltd<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-8\">\n\t<td class=\"column-1\">Zincidone <\/td><td class=\"column-2\">Solabia Group<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-9\">\n\t<td class=\"column-1\">Natori ZPCA 95<\/td><td class=\"column-2\">Ecoori<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-10\">\n\t<td class=\"column-1\">ILLUMISCIN <\/td><td class=\"column-2\">Rahn AG<\/td><td class=\"column-3\">Glycerin , Aqua (Aqua) , Olea Europaea (Olive) Leaf Extract , Ascorbyl Glucoside , Zinc PCA , Ascorbic Acid<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-11\">\n\t<td class=\"column-1\">EcoCar  Zinclean<\/td><td class=\"column-2\">Ecochem Specialities Ltd.<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-12\">\n\t<td class=\"column-1\">AJIDEW  ZN-100<\/td><td class=\"column-2\">Ajinomoto OmniChem<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-13\">\n\t<td class=\"column-1\">AJIDEW  ZN-100N<\/td><td class=\"column-2\">Ajinomoto OmniChem<\/td><td class=\"column-3\">Zinc PCA<\/td><td class=\"column-4\">Certified for organic cosmetics<\/td>\n<\/tr>\n<tr class=\"row-14\">\n\t<td class=\"column-1\">PHYSIOGENYL  Powder<\/td><td class=\"column-2\">Solabia Group<\/td><td class=\"column-3\">Magnesium PCA , Manganese PCA , Zinc PCA , Sodium PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-15\">\n\t<td class=\"column-1\">PHYSIOGENYL <\/td><td class=\"column-2\">Solabia Group<\/td><td class=\"column-3\">Sodium PCA , Magnesium PCA , Zinc PCA , Manganese PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-16\">\n\t<td class=\"column-1\">SHAROHYAL OLIGO<\/td><td class=\"column-2\">Sharon Personal Care Srl<\/td><td class=\"column-3\">Aqua , Glycerin , Lentinus Edodes Extract , Tremella Fuciformis (Mushroom) Extract , Zinc PCA , Copper PCA<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<tr class=\"row-17\">\n\t<td class=\"column-1\">PRODEW 700<\/td><td class=\"column-2\">Ajinomoto OmniChem<\/td><td class=\"column-3\">Sodium PCA , Glutamic Acid , Aqua , Sodium Polyaspartate , Butylene Glycol , Betaine , Zinc PCA , Sodium Citrate , Arginine , Serine , Lysine HCl<\/td><td class=\"column-4\"><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<!-- #tablepress-467 from cache -->\n<h3>Conclusion: Zinc PCA<\/h3>\n<p>To facilitate rapid market entry, <a href=\"http:\/\/www.tojocosmetics.de\" target=\"_blank\" rel=\"noopener\">Tojo Cosmetics<\/a> offers EU-compliant white-label products that are already formulated with sebum-regulating active ingredients such as zinc PCA.<\/p>\n<p>For custom product development, <a href=\"http:\/\/www.cosactive.de\" target=\"_blank\" rel=\"noopener\">Cosactive<\/a> offers formulation-tested active ingredients and functional blends starting at low usage levels.<\/p>\n<p>During development, pH stability, electrolyte compatibility, and the target product should be taken into account.<\/p>\n<p><a href=\"https:\/\/www.cosmacon.de\/en\/contact\/enquiry\/\" target=\"_blank\" rel=\"noopener\">Please feel free to contact us regarding custom formulation development.<\/a><\/p>\n<h3>FAQ<\/h3>\n<p><strong>What is Zinc PCA?<\/strong><\/p>\n<p>Zinc PCA is a zinc salt of pyrrolidone carboxylic acid and a component of modern sebum-regulating skincare.<\/p>\n<p><strong>What is the effect of Zinc PCA?<\/strong><\/p>\n<p>It reduces excess sebum, supports the skin barrier, and possesses antimicrobial properties.<\/p>\n<p><strong>Is Zinc PCA suitable for acne?<\/strong><\/p>\n<p>Yes, the active ingredient is frequently used in skincare products for oily and acne-prone skin.<\/p>\n<p><strong>Is zinc PCA permitted in the EU?<\/strong><\/p>\n<p>Yes, the active ingredient is permitted for cosmetic use and is not subject to restrictions.<\/p>\n<p><strong>What concentrations are used?<\/strong><\/p>\n<p>Typical concentrations range from 0.1% to 1.0%.<\/p>\n<p><strong>Why is zinc PCA difficult to formulate?<\/strong><\/p>\n<p>Zinc ions can form insoluble complexes with other anions.<\/p>\n<p><strong>Does every product containing zinc PCA require a CPSR?<\/strong><\/p>\n<p>Yes, every cosmetic formulation requires its own safety assessment.<\/p>\n<p><strong>Literature:<\/strong><\/p>\n<p><a href=\"https:\/\/www.cosmacon.de\/wp-content\/uploads\/2026\/03\/Datasheet-2.pdf\">AJIDEW\u00ae ZN-100 \/ Zinc PCA<\/a><\/p>\n<p>PubMed references on the dermatological significance of zinc:<\/p>\n<ul>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/17147561\/\"><u>https:\/\/pubmed.ncbi.nlm.nih.gov\/17147561\/<\/u><\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23493187\/\"><u>https:\/\/pubmed.ncbi.nlm.nih.gov\/23493187\/<\/u><\/a><\/li>\n<li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/21393982\/\"><u>https:\/\/pubmed.ncbi.nlm.nih.gov\/21393982\/<\/u><\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Quick Answer \/ Definition Zinc PCA (INCI: Zinc PCA) is the zinc salt of pyrrolidone carboxylic acid (PCA), a natural component of the skin\u2019s Natural Moisturizing Factor (NMF). The active ingredient combines the sebum-regulating properties of zinc with the moisture-binding properties of PCA. In cosmetic formulations, zinc PCA is primarily used in products for&hellip;<\/p>\n","protected":false},"author":2,"featured_media":19701,"template":"","class_list":["post-19671","encyclopedia","type-encyclopedia","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Zinc PCA in Cosmetics \u2013 Effects, Formulation and Regulatory - Cosmacon<\/title>\n<meta name=\"description\" content=\"Zinc PCA in cosmetics: benefits, sebum regulation, formulation challenges and applications in skin and scalp care\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cosmacon.de\/en\/glossary\/zinc-pca-in-cosmetics-effects-formulation-and-regulatory\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zinc PCA in Cosmetics \u2013 Effects, Formulation and Regulatory - 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