{"id":16747,"date":"2025-02-15T21:15:12","date_gmt":"2025-02-15T20:15:12","guid":{"rendered":"https:\/\/www.cosmacon.de\/?post_type=encyclopedia&p=16747"},"modified":"2025-02-16T12:09:27","modified_gmt":"2025-02-16T11:09:27","slug":"acetyl-hexapeptide-8-the-innovative-solution-for-youthful-skin","status":"publish","type":"encyclopedia","link":"https:\/\/www.cosmacon.de\/en\/glossary\/acetyl-hexapeptide-8-the-innovative-solution-for-youthful-skin\/","title":{"rendered":"Acetyl Hexapeptide-8: The innovative solution for youthful skin"},"content":{"rendered":"

Acetyl Hexapeptide 8, also known as Argireline, has established itself as a breakthrough active ingredient in the cosmetics industry in recent years. With its versatile application possibilities and scientifically proven effects, it is a must-have in anti-aging products. In this blog post, we take a look at the properties, effects, benefits and challenges of this innovative active ingredient and provide insights into possible product ideas.<\/p>\n

 <\/p>\n

Physicochemical properties of acetyl hexapeptide-8<\/h3>\n

Acetyl hexapeptide-8 is a white, flaky crystalline powder with a purity of \u226598%. It is water-soluble and has a recommended use concentration of 0.000001 to 2%. The active ingredient mimics the N-terminal end of the protein SNAP-25 and thereby influences the formation of the SNARE complex, which inhibits the release of neurotransmitters and thus reduces muscle contraction.<\/p>\n

 <\/p>\n

A brief excursion to Snap-25: How does SNAP-25 work?<\/h3>\n

SNAP-25 (Synaptosomal-Associated Protein 25) is a protein that plays an important role in communication between nerve cells. It belongs to the family of SNARE proteins, which are responsible for the fusion of cell membranes \u2013 a process that is necessary for the release of neurotransmitters.<\/p>\n

SNAP-25 is part of the SNARE complex, which is necessary for the fusion of vesicles (small bubbles containing neurotransmitters) with the cell membrane.<\/p>\n

As a result, messenger substances (neurotransmitters) are released into the synaptic cleft and enable the transmission of nerve signals.<\/p>\n

 <\/p>\n

Cooperation with other proteins:<\/strong><\/p>\n

SNAP-25 works with syntaxin and synaptobrevin (VAMP-2) to enable vesicle fusion.<\/p>\n

These proteins form a kind of molecular \u201czipper\u201d that pulls the membranes together and triggers fusion.<\/p>\n

 <\/p>\n

Effect of Botox (botulinum toxin):<\/strong><\/p>\n

Botulinum toxin cleaves SNAP-25, thus preventing the release of neurotransmitters such as acetylcholine.<\/p>\n

This prevents muscles from contracting, causing temporary paralysis \u2013 an effect that is used in aesthetic medicine to reduce wrinkles.<\/p>\n

 <\/p>\n

Why is SNAP-25 important?<\/strong><\/p>\n

It is important for nerve function and muscle control.
\nIt plays a role in learning and memory processes because it influences signal transmission in the brain.<\/p>\n

Mutations or malfunctions of SNAP-25 are associated with neurological disorders such as epilepsy or schizophrenia.<\/p>\n

 <\/p>\n

In short, SNAP-25 is a key protein for nerve signaling, and Botox uses its blockade to inhibit muscle movement.<\/strong><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

Summary of chemical data Acetyl Hexapeptide 8<\/h3>\n

INCI name: Acetyl Hexapeptide-8<\/p>\n

CAS number: 616204-22-9<\/p>\n

Molecular weight: approx. 888.99 g\/mol<\/p>\n

Appearance: white powder or crystals<\/p>\n

Solubility: water-soluble<\/p>\n

Recommended concentration: 0.01 % – 2 %; power products up to 20%<\/p>\n

pH range: stable between 4.0 and 7.0<\/p>\n

 <\/p>\n

Efficacy results and optimal concentration<\/h3>\n

Acetyl Hexapeptide 8 shows impressive results in reducing wrinkles. Studies on 31 subjects aged 35 to 60 years who applied an emulsion with 0.2% Acetyl Hexapeptide-8 twice daily showed significant improvements in wrinkle depth and number after four weeks.<\/p>\n

The recommended concentration for maximum efficacy is 0.05\u20130.2%, although noticeable results can be seen at lower dosages.<\/p>\n

 <\/p>\n

Advantages Acetyl Hexapeptide 8<\/h3>\n

Anti-aging effect: Acetyl Hexapeptide 8 reduces dynamic wrinkles, which are caused by repeated muscle contractions, giving the skin a smooth appearance.<\/p>\n

Safety: The active ingredient is gentle on the skin and does not cause side effects such as rigid facial expressions often associated with more invasive procedures.<\/p>\n

Wide applicability: The active ingredient is suitable for various product formats, including gels, creams, serums and emulsions.<\/p>\n

Non-invasive: Acetyl Hexapeptide-8 offers a painless alternative to Botox injections, ideal for people who don’t want invasive procedures.<\/p>\n

 <\/p>\n

Disadvantages of Acetyl Hexapeptide 8<\/h3>\n

Sensitivity to concentration: Using too high a dosage can reduce effectiveness or lead to unwanted results.<\/p>\n

Slow results for deeper wrinkles: Although the active ingredient reduces dynamic wrinkles, it may take longer for it to show visible results for deeper wrinkles.<\/p>\n

Cost: Highly pure peptides like Acetyl Hexapeptide-8 can be costly to produce, which affects the final price of products.<\/p>\n

 <\/p>\n

Ideas for using cosmetic products<\/h3>\n

Thanks to its versatility and efficacy, Acetyl Hexapeptide-8 is ideal for the following product categories:<\/p>\n

Anti-aging serums: With high concentrations of peptides for targeted wrinkle reduction.<\/p>\n

Day and night creams: Combined with moisturizers for smooth, hydrated skin.<\/p>\n

Eye creams: To reduce crow’s feet and fine lines around the eyes.<\/p>\n

Face masks: For intensive treatment of tired or stressed skin.<\/p>\n

Primers: Cosmetic formulations that smooth the skin and serve as a make-up base.<\/p>\n

 <\/p>\n

We like to use the following active ingredients based on acetyl hexapeptide-8:<\/strong><\/p>\n

\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t
Name<\/strong><\/th>Company Name<\/strong><\/th>INCI Name<\/strong><\/th>Remarks<\/strong><\/th>\n<\/tr>\n<\/thead>\n
Acetyl Hexapeptide-8<\/td>COSROMA<\/td>Acetyl Hexapeptide-8<\/td><\/td>\n<\/tr>\n
Acetyl Hexapeptide-8 Liquid<\/td>COSROMA<\/td>Aqua , Pentylene Glycol , 1,2-Hexanediol , Acetyl Hexapeptide-8<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae AH8P (Acetyl Hexapeptide-8)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8<\/td><\/td>\n<\/tr>\n
ELIPH-1: Anti-Wrinkle, Elastic Liposomes Encapsulating Acetyl Hexapeptide 8 and Vitamin E<\/td>NanoVec<\/td>Aqua (Aqua) , Hydrogenated Phosphatidylcholine , Caprylic\/Capric Triglyceride , Linoleic Acid , Acetyl Hexapeptide-8 , Tocopheryl Acetate , Propanediol , Caprylyl Glycol<\/td><\/td>\n<\/tr>\n
Peptidox L<\/td>Gfn-Selco<\/td>Aqua , Caprylyl Glycol , Acetyl Hexapeptide-8<\/td><\/td>\n<\/tr>\n
Peptidox P<\/td>Gfn-Selco<\/td>Acetyl Hexapeptide-8<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae SC-AH8 0.3% (Acetyl Hexapeptide-8)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Caprylyl Glycol , Ethylhexylglycerin , Glycerin , Aqua<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae SC-AH8 0.05% (Acetyl Hexapeptide-8)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Caprylyl Glycol , Ethylhexylglycerin , Aqua<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae SC-AH8 0.1% (Acetyl Hexapeptide-8)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Caprylyl Glycol , Ethylhexylglycerin , Aqua<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae SC-AH8 (C 0.05%) (Acetyl Hexapeptide-8)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Caprylyl Glycol , Aqua<\/td><\/td>\n<\/tr>\n
Creapep\u00ae Acetyl Hexapeptide-8<\/td>Tidetron Bioworks<\/td>Acetyl Hexapeptide-8<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae Blends (40%)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Acetyl Octapeptide-3 , Acetyl Tetrapeptide-5 , Trehalose , Aqua , Caprylyl Glycol , Ethylhexylglycerin<\/td><\/td>\n<\/tr>\n
Acetyl Hexapeptide-8 0.2% Solution<\/td>Active Peptide Company<\/td>Acetyl Hexapeptide-8<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae SC-AH8 (0.1%)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Caprylyl Glycol , Ethylhexylglycerin , Aqua , Glycerin<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae SC-AH8 (0.2%)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Caprylyl Glycol , Ethylhexylglycerin , Aqua , Glycerin<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae SC-AH8 (0.3%)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Caprylyl Glycol , Ethylhexylglycerin , Aqua , Glycerin<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae SC-AH8 (0.05%)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Caprylyl Glycol , Ethylhexylglycerin , Aqua , Glycerin<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae SC-AH8 (C 0.05%)<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Aqua , Caprylyl Glycol<\/td><\/td>\n<\/tr>\n
WrinFix-H8<\/td>Shenzhen Readline Biotech Co.,Ltd.<\/td>Acetyl Hexapeptide-8<\/td><\/td>\n<\/tr>\n
SpecPed\u00ae NIP Liposome<\/td>Spec-Chem Industry Inc<\/td>Acetyl Hexapeptide-8 , Dipeptide Diaminobutyroyl Benzylamide Diacetate , Arginine<\/td><\/td>\n<\/tr>\n
SunPEP AHP-500(H)<\/td>SUNFINE GLOBAL Co., Ltd.<\/td>Acetyl Hexapeptide-8 , 1,2-Hexanediol , Aqua <\/td><\/td>\n<\/tr>\n
Acetyl Hexapeptide-8 Pure Powder<\/td>Active Peptide Company<\/td>Acetyl Hexapeptide-8<\/td><\/td>\n<\/tr>\n
WKPep\u00ae Octa<\/td>Shenzhen Winkey Technology Co., Ltd.<\/td>Acetyl Octapeptide-3 , Pentylene Glycol , 1,2-Hexanediol , Aqua <\/td><\/td>\n<\/tr>\n
iActive Lifting<\/td>KimiKa, LLC (Formerly Cosphatech)<\/td>Aqua , Butylene Glycol , Glycerin , Acetyl Hexapeptide-8 , Tamarindus Indica Seed Gum , Phenoxyethanol , Cucumis Sativus (Cucumber) Fruit Extract , Oryza Sativa (Rice) Extract , Honey Extract , Fucus Vesiculosus Extract , Adenosine , Ethylhexylglycerin , Cellulose Gum , Chondrus Crispus Powder , Ammonium Acryloyldimethyltaurate\/VP Copolymer , PVP<\/td><\/td>\n<\/tr>\n
SHINE+Freeze-Aging Peptide<\/td>Uniproma<\/td>Arginine\/Lysine Polypeptide , Dipeptide Diaminobutyroyl Benzylamide Diacetate , Acetyl Hexapeptide-8 , Glyceryl Glucoside , Aqua , Glycerin , Pentylene Glycol , Betaine , Propanediol<\/td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/p>\n

 <\/p>\n

Summary<\/h3>\n

Acetyl Hexapeptide 8 is a true game changer in the cosmetics industry. It offers an effective, safe and non-invasive solution for reducing wrinkles and promoting youthful skin. Although the active ingredient comes with costs and specific application requirements, its advantages far outweigh these.<\/p>\n

If you are interested in developing innovative products with Acetyl Hexapeptide-8 for your brand, Cosmacon GmbH offers customized solutions. With cutting-edge technology and scientific expertise, we can develop unique products that will delight your customers.<\/a><\/p>\n

 <\/p>\n

Literature:<\/strong><\/p>\n

Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with\u00a0Acetyl<\/strong>\u00a0Hexapeptide<\/strong>–8<\/strong>\u00a0and Epidermal Growth Factor on Korean Skin.<\/a><\/p>\n

An JH, Lee HJ, Yoon MS, Kim DH.Ann Dermatol. 2019 Jun;31(3):263-271.<\/p>\n

Polydioxanone Bioactive Sutures-Acetyl<\/strong>\u00a0Hexapeptide<\/strong>–8<\/strong>\u00a0(Argireline): An Intelligent System for Controlled Release in Facial Harmonization.<\/a><\/p>\n

Velazco de Maldonado GJ, Su\u00e1rez-Vega DV, Miller-Kobisher B, Garc\u00eda-Guevara VJ.J Cutan Aesthet Surg. 2023 Oct-Dec;16(4):325-334.<\/p>\n

Skin scars and wrinkles temporary camouflage in dermatology and oncoesthetics: focus on\u00a0acetyl<\/strong>\u00a0hexapeptide<\/strong>–8<\/strong>.<\/a><\/p>\n

Palmieri B, Noviello A, Corazzari V, Garelli A, Vadala M.Clin Ter. 2020 Nov-Dec;171(6):e539-e548.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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